The first settlers arrived in Wyoming in 1855. They were six German and Dutch families from Pennsylvania, shortly joined by families from Chicago and St. Paul. They named the site "Wyoming" because it reminded them of the Wyoming Valley in Pennsylvania. "Wyoming" is an Algonquin word for "large plains" or "extensive meadows". Many descendants of the original settlers still thrive in the area.The spot where the first structure was built is marked by a memorial stone. It's in a small park on the southeast corner of 270th Street and Felton Avenue. In those days, it would have overlooked the Sunrise River, just to the North. When Wyoming was founded, there were only 225 houses in St. Paul.

The Village Hall was located in several places in Wyoming's history, fairly recently in a gas station on Forest Boulevard, where the safe's combination was written on the wall, prominently. In 1977 the present City Hall was dedicated. It was funded partly by a federal development grant that a new Congressman named Jim Oberstar helped obtain.